Francoise Hubert

Francoise Hubert

Laboratoire Santé Environnement et Microbiologie (PDG-RBE-SG2M-LSEM)

Contact par courriel

02 40 37 43 39

Fax : 02 40 37 40 75

Employeur : Ifremer

Site : Nantes

Adresse postale : Centre Atlantique - Rue de l'Ile d'Yeu - BP 21105 - 44311 Nantes Cedex 03




Hubert Francoise, Morga Benjamin, Renault Tristan, Le Guyader Soizick (2017). Adsorption of norovirus and ostreid herpesvirus type 1 to polymer membranes for the development of passive samplers . Journal Of Applied Microbiology , 122(4), 1039-1047 .
Vincent-Hubert Francoise, Uher Emmanuelle, Di Giorgio Carole, Michel Cecile, De Meo Michel, Gourlay-France Catherine (2017). Use of low density polyethylene membranes for assessment of genotoxicity of PAHs in the Seine River . Ecotoxicology , 26(2), 165-172 .


Garry Pascal, Le Saux Jean-Claude, Hervio Heath Dominique, Le Guyader Soizick (2016). Rapport d’activités 2015. Laboratoire Santé Environnement et Microbiologie. Laboratoire National de Référence de Microbiologie des coquillages .
Lapegue Sylvie, Renault Tristan, Bechemin Christian, Le Guyader Soizick, Stavrakakis Christophe, Rivet Florence (2016). Rapport d'activités 2015 de l'Unité SG2M : Santé, Génétique et Microbiologie des Mollusques .


Michel Cecile, Vincent Hubert Francoise (2015). DNA oxidation and DNA repair in gills of zebra mussels exposed to cadmium and benzo(a)pyrene . Ecotoxicology , 24(9), 2009-2016 .
Renault Tristan, Lapegue Sylvie, Le Guyader Soizick, Hatt Philippe-Jacques, Rivet Florence (2015). Rapport d'activités 2014 de l'Unité SG2M. Santé, Génétique et Microbiologie des mollusques .
Chatel Annelle, Faucet-Marquis Virginie, Gourlay-France Catherine, Pfohl-Leszkowicz Annie, Hubert Francoise (2015). Genotoxicity and activation of cellular defenses in transplanted zebra mussels Dreissena polymorpha along the Seine river . Ecotoxicology And Environmental Safety , 114, 241-249 . Publisher's official version : , Open Access version :


Chatel Amelie, Faucet-Marquis Virginie, Pfohl-Leszkowicz Annie, Gourlay-France Catherine, Vincent Hubert Francoise (2014). DNA adduct formation and induction of detoxification mechanisms in Dreissena polymorpha exposed to nitro-PAHs . Mutagenesis , 29(6), 457-465 . Publisher's official version : , Open Access version :
Vincent-Hubert Francoise, Chatel Amelie, Gourlay-France Catherine (2014). Metallothionein mRNA induction is correlated with the decrease of DNA strand breaks in cadmium exposed zebra mussels . Mutation Research-genetic Toxicology And Environmental Mutagenesis , 766, 10-15 . Publisher's official version : , Open Access version :


Michel Cecile, Bourgeault Adeline, Gourlay-France Catherine, Palais Frederic, Geffard Alain, Vincent-Hubert Francoise (2013). Seasonal and PAH impact on DNA strand-break levels in gills of transplanted zebra mussels . Ecotoxicology And Environmental Safety , 92, 18-26 .


Chatel Amelie, Faucet-Marquis Virginie, Perret Marine, Gourlay-France Catherine, Uher Emmanuelle, Pfohl-Leszkowicz Annie, Vincent-Hubert Francoise (2012). Genotoxicity assessment and detoxification induction in Dreissena polymorpha exposed to benzo[a]pyrene . Mutagenesis , 27(6), 703-711 . Publisher's official version : , Open Access version :
Vincent-Hubert Francoise, Revel Messika, Garric Jeanne (2012). DNA strand breaks detected in embryos of the adult snails, Potamopyrgus antipodarum, and in neonates exposed to genotoxic chemicals . Aquatic Toxicology , 122, 1-8 .
Michel Cecile, Vincent-Hubert Francoise (2012). Detection of 8-oxodG in Dreissena polymorpha gill cells exposed to model contaminants . Mutation Research-genetic Toxicology And Environmental Mutagenesis , 741(1-2), 1-6 .
Hubert Francoise, Moisan Karine, Munschy Catherine, Tronczynski Jacek (2012). Mutagenicity and genotoxicity of suspended particulate matter in the Seine river estuary . Mutation Research-genetic Toxicology And Environmental Mutagenesis , 741(1-2), 7-12 . Publisher's official version : , Open Access version :


Gourlay France Catherine, Vincent-Hubert Francoise, Tusseau-Vuillemin Marie-Helene, Sanchez Wilfried, Geffard Alain, Levi Yves, Oziol Lucie, Labadie Pierre, Mouchel Jean-Marie, Raguet Mireille, Thery Sylvain (2011). Le risque écotoxicologique dans le bassin de la Seine. Comprendre et diagnostiquer l'impact de la contamination sur les organismes . PIREN-SEINE n°12 .
Vincent-Hubert Francoise, Arini Adeline, Gourlay-France Catherine (2011). Early genotoxic effects in gill cells and haemocytes of Dreissena polymorpha exposed to cadmium, B[a]P and a combination of B[a]P and Cd . Mutation Research-genetic Toxicology And Environmental Mutagenesis , 723(1), 26-35 .


Fechner Lise, Vincent-Hubert Francoise, Gaubert Philippe, Bouchez Theodore, Gourlay-France Catherine, Tusseau-Vuillemin Marie-Helene (2010). Combined eukaryotic and bacterial community fingerprinting of natural freshwater biofilms using automated ribosomal intergenic spacer analysis . Fems Microbiology Ecology , 74(3), 542-553 .
Bourgeault A., Gourlay-France C., Vincent-Hubert Francoise, Palais F., Geffard A., Biagianti-Risbourg S., Pain-Devin S., Tusseau-Vuillemin Marie-Helene (2010). Lessons from a Transplantation of Zebra Mussels into a Small Urban River: An Integrated Ecotoxicological Assessment . Environmental Toxicology , 25(5), 468-478 .
Garric Jeanne, Morin Soizic, Vincent-Hubert Francoise (2010). Les biomarqueurs en écotoxicologie : définition, intérêt, limite, usage . Revue SET - Sciences, eaux & territoires , 10(1), 12-19 .
Chaumot Arnaud, Morin Soizic, Vincent-Hubert Francoise, Montuelle Bernard (2010). Focus : Adaptation des espèces et contamination des milieux ? Revue SET - Sciences, eaux & territoires , 10(1), 30-33 .


Tronczynski Jacek, Munschy Catherine, Moisan Karine (2007). Organic contaminants that leave traces. Sources, transport and fate .
Hubert-Vincent Francoise (2007). Diversité génétique et adaptation des espèces aquatiques en milieu anthropisé . R.INT.DCN-BE-EX/2007.01/NANTES .


Tronczynski Jacek, Munschy Catherine, Moisan Karine (2004). Les contaminants organiques qui laissent des traces. Sources, transport et devenir .


Akcha Farida, Hubert Francoise, Pfhol-Leszkowicz A (2003). Potential value of the comet assay and DNA adduct measurement in dab (Limanda limanda) for assessment of in situ exposure to genotoxic compounds . Mutation Research Genetic Toxicology And Environmental Mutagenesis , 534(1-2), 21-32 .


Tronczynski Jacek, Moisan Karine, Munschy Catherine, Truquet Isabelle, Vincent Hubert Francoise (2001). Assessment of antifouling agents in coastal environments (ACE). ACE Project – MAST3 PL971620. Contribution to Major Report 2 .


Mitta Guillaume, Hubert Francoise, Dyrynda Ea, Boudry Pierre, Roch Philippe (2000). Mytilin B and MGD2, two antimicrobial peptides of marine mussels: gene structure and expression analysis . Developmental And Comparative Immunology , 24(4), 381-393 .
Hubert Francoise (2000). cDNA cloning and expression of two Ki-ras genes in the flounder, Platichthys flesus, and analysis of hepatic neoplasms . Comparative Biochemistry And Physiology B Biochemistry And Molecular Biology , 126(1), 17-27 .
Mitta Guillaume, Vandenbulcke F, Hubert Francoise, Salzet M, Roch Philippe (2000). Involvement of mytilins in mussel antimicrobial defense . Journal Of Biological Chemistry , 275(17), 12954-12962 .
Cachot Jerome, Cherel Y, Galgani Francois, Vincent Francoise (2000). Evidence of p53 mutation in an early stage of liver cancer in European flounder, Platichthys flesus (L.) . Mutation Research Genetic Toxicology And Environmental Mutagenesis , 464(2), 279-287 .


Galgani Francois, Piel Nathalie, Vincent Francoise (1999). A simple procedure for polymerase chain reaction of the PSBA gene in algae: application to the screening of mutations conferring atrazine resistance and discrimination of natural populations of Porphyra linearis . Comparative Biochemistry And Physiology B-biochemistry & Molecular Biology , 124(4), 363-369 .


Cachot Jerome, Galgani Francois, Vincent Francoise (1998). cDNA cloning and expression analysis of flounder p53 tumour suppressor gene . Comparative Biochemistry And Physiology B-biochemistry & Molecular Biology , 121(3), 235-242 .
Cachot Jerome, Galgani Francois, Vincent Francoise (1998). Production of a polyclonal antibody raised against recombinant flounder p53 protein . Comparative Biochemistry And Physiology C-pharmacology Toxicology & Endocrinology , 120(3), 351-356 .
Vincent Francoise, De Boer J, Pfohl-Leszkowicz A, Cherrel Y, Galgani Francois (1998). Two cases of ras mutation associated with liver hyperplasia in dragonets (Callionymus lyra) exposed to polychlorinated biphenyls and polycyclic aromatic hydrocarbons . Molecular Carcinogenesis , 21(2), 121-127 .<121::AID-MC6>3.3.CO;2-M
Gemma A, Hagiwara K, Vincent Francoise, Ke Y, Hancock Ar, Nagashima M, Bennett Wp, Harris Cc (1998). hSmad5 gene, a human hSmad family member: its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors . Oncogene , 16(7), 951-956 .


Vincent-Hubert Francoise, Nagashima M, Takenoshita S, Khan Ma, Gemma A, Hagiwara K, Bennett Wp (1997). Mutation analysis of the transforming growth factor-beta type II receptor in human cell Lines resistant to growth inhibition by transforming growth factor-beta . Oncogene , 15(1), 117-122 .
Giraud Gerard, Vincent Francoise, Alzieu Claude, Quiniou Francoise (1997). Stratégie vis-à-vis des sédiments contaminés .


Vincent-Hubert Francoise, Hagiwara K, Ke Y, Stoner Gd, Demetrick Dj, Bennett Wp (1996). Mutation analysis of the transforming growth factor beta type II receptor in sporadic human cancers of the pancreas, liver, and breast . Biochemical And Biophysical Research Communications , 223(3), 561-564 .
Hubert Florence, Van Der Knaap Wil, Noel Thierry, Roch Philippe (1996). Cytotoxic and antibacterial properties of Mytilus galloprovincialis, Ostrea edulis and Crassostrea gigas (bivalve molluscs) hemolymph . Aquatic Living Resources , 9(2), 115-124 . Publisher's official version : , Open Access version :


Vincent Francoise, Jaunet Stephane, Galgani Francois, Besselink Harry, Koeman Jan (1995). Expression of ras Gene in Flounder (Platichtys flesus) and Red Mullet (Mullus barbatus) . Biochemical And Biophysical Research Communications , 215(2), 659-665 .
Vincent Francoise (1995). Analyse moléculaire de la mutagénèse : étude de l'activation du proto-oncogène ras chez Callionymus lyra et Mullus barbatus .
Galgani Francois, Burgeot Thierry, Bocquene Gilles, Vincent Francoise, Leaute Jean-Pierre, Labastie Jacques, Forest Andre, Guichet Roger (1995). Distribution and abundance of debris on the continental shelf of the Bay of Biscay and in Seine Bay . Marine Pollution Bulletin , 30(1), 58-62 .


Burgeot Thierry, Bocquene Gilles, Pingray G, Godefroy Dominique, Legrand Julien, Dimeet Joel, Marco Francoise, Vincent Francoise, Henocque Yves, Oger-Jeanneret Helene, Galgani Francois (1994). Monitoring biological effects of contamination in marine fish along French coasts by measurement of ethoxyresorufin-O-deethylase activity . Ecotoxicology And Environmental Safety , 29(2), 131-147 .
Vincent Francoise, Corral Debrinski M, Adolphe M (1994). Transient mitochondrial transcript level decay in oxidative stressed chondrocytes . Journal Of Cellular Physiology , 158(1), 128-132 .
Galgani Francois, Vincent-Hubert Francoise (1994). Direct polymerase chain reaction from live algae . Journal of Marine Biotechnology , 2, 1-5 .
Vincent Francoise, Cachot Jerome, Galgani Francois, Bocquene Gilles (1994). Réponse des organismes marins aux polluants bases biologiques et moléculaires .


Vincent Francoise (1993). Rapport relatif au projet d'étude en génotoxicité de l'environnement marin .


Michel C., Vincent Francoise, Duval C, Poelman M., Adolphe M (1992). Toxic effects and detection of oxygen free radicals on cultured articular chondrocytes generated by menadione. Free Radical Research Communications , 17(4), 279-289 .
Flour Mp, Ronot X, Vincent Francoise, Benoit Benedicte, Adolphe M (1992). Differential temperature sensitivity of cultured cells from cartilaginous or bone origin. Biology Of The Cell , 75(1), 83-87 .


Vincent Francoise, Corral M, Defer N, Adolphe M (1991). Effects of oxygen free radicals on articular chondrocytes in culture: c-myc and c-Ha-ras messenger RNAs and proliferation kinetics. Experimental Cell Research , 192(2), 333-339 .
Adolphe M, Thenet S, Vincent Francoise, Demignot S (1991). Monolayer, tridimensional and immortalized cell line cultures as models in pharmacology and toxicology . Toxicology In Vitro , 5(5-6), 367-371 .


Vincent Francoise, Brun H, Clain E, Ronot X, Adolphe M (1989). Effects of oxygen-free radicals on proliferation kinetics of cultured rabbit articular chondrocytes . Journal Of Cellular Physiology , 141(2), 262-266 .

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